Neurofilament light increases over time in severe COVID-19 and is associated with delirium

PJ Smeele, L Vermunt, S Blok, JW Duitman… - Brain …, 2022 - academic.oup.com
Neurological monitoring in sedated Intensive Care Unit patients is constrained by the lack of
reliable blood-based biomarkers. Neurofilament light is a cross-disease biomarker for …

A multi-and mixed-method adaptation study of a patient-centered perioperative mental health intervention bundle

J Abraham, A Meng, A Baumann, KJ Holzer… - BMC health services …, 2023 - Springer
Background Anxiety and depression are common among older adults and can intensify
during perioperative periods, but few mental health interventions are designed for older …

A perioperative mental health intervention for depressed and anxious older surgical patients: results from a feasibility study

J Abraham, KJ Holzer, EM Lenard, A Meng… - The American Journal of …, 2024 - Elsevier
Objectives The perioperative period is challenging and stressful for older adults. Those with
depression and/or anxiety have an increased risk of adverse surgical outcomes. We …

Evaluation of the delirium preventive effect of dual orexin receptor antagonist (DORA) in critically ill adult patients requiring ventilation with tracheal intubation at an …

A Matsuoka, R Sogawa, T Murakawa-Hirachi… - General Hospital …, 2023 - Elsevier
Objective ICU delirium reportedly contributes to increased mortality attributed to underlying
diseases, long-term cognitive decline, and increased healthcare costs. Dual orexin receptor …

In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization

R Kaushik, GJ McAvay, TE Murphy… - JAMA Network …, 2024 - jamanetwork.com
Importance Older adults who are hospitalized for COVID-19 are at risk of delirium. Little is
known about the association of in-hospital delirium with functional and cognitive outcomes …

Delirium in older adults: what a surgeon needs to know

G Melegari, A Gaspari, E Gualdi, M Zoli, S Meletti… - Surgeries, 2022 - mdpi.com
Delirium remains a challenging clinical problem in hospitalized older adults, especially for
postoperative patients. This complication, with a high risk of postoperative mortality and an …

Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study

JCG de Alencar, FB Garcez, AAS Pinto, LOJ Silva… - Scientific reports, 2023 - nature.com
Delirium is a common, serious, and often preventable neuropsychiatric emergency mostly
characterized by a disturbance in attention and awareness. Systemic insult and …

Rationale, design, and characteristics of the VALIANT (CO V ID‐19 in older adults: AL ong i tudinal A ssessme nt) cohort

AB Cohen, GJ McAvay, M Geda… - Journal of the …, 2023 - Wiley Online Library
Background Most older adults hospitalized with COVID‐19 survive their acute illness. The
impact of COVID‐19 hospitalization on patient‐centered outcomes, including physical …

Delirium variability is influenced by the sound environment (DEVISE study): how changes in the intensive care unit soundscape affect delirium incidence

A Sangari, EA Emhardt, B Salas, A Avery… - Journal of medical …, 2021 - Springer
Quantitative data on the sensory environment of intensive care unit (ICU) patients and its
potential link to increased risk of delirium is limited. We examined whether higher average …

Transcutaneous electrical acupoint stimulation combined with auricular acupressure reduces postoperative delirium among elderly patients following major …

Q Fan, C Lei, Y Wang, N Yu, L Wang, J Fu… - Frontiers in …, 2022 - frontiersin.org
Background Postoperative delirium is common in elderly patients following major surgery.
This study aimed to assess the effect of transcutaneous electrical acupoint stimulation …