Distinct tumor microenvironment forms in each progression step of cancer and has diverse
capacities to induce both adverse and beneficial consequences for tumorigenesis. It is now …

The tumour microenvironment (TME) is composed of extracellular matrix and non-mutated
cells supporting tumour growth and development. Tumour-associated macrophages (TAMs) …

Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and
escape from immunity via T cell suppression. Initially, these myeloid cells were identified as …

The immunosuppressive tumor microenvironment (TME) is a major barrier to
immunotherapy. Within solid tumors, why monocytes preferentially differentiate into …

Tumor-associated macrophages (TAM) are exposed to multiple microenvironmental cues in
tumors, which collaborate to endow these cells with protumoral activities. Hypoxia, caused …

Macrophages are the dominant leukocyte population found in the tumor microenvironment.
Accumulating evidence suggests that these tumor-associated macrophages (TAMs) actively …

With 5-year survival rates remaining constant at 6% and rising incidences associated with
an epidemic in obesity and metabolic syndrome, pancreatic ductal adenocarcinoma (PDAC) …

Tumor-associated macrophages (TAM) are an important component of the tumor stroma and
exert several tumor-promoting activities. Strongly pro-angiogenic TAMs that reside in …

Hepatocellular carcinoma (HCC) is among the most prevalent and lethal cancers in the
human population. HCC is an inflammation-associated cancer caused by different …

The current review article describes the functional relationship between tumor-associated
macrophages (TAM) as key cellular contributors to cancer malignancy on the one hand and …