Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to
be a challenge in cancer treatment. Chemoresistance is influenced by genetic and …

The extracellular matrix (ECM) is an important component of the tumor microenvironment
(TME), having several important roles related to the hallmarks of cancer. In cancer, multiple …

Cellular senescence describes an irreversible growth arrest characterized by distinct
morphology, gene expression pattern, and secretory phenotype. The final or intermediate …

High numbers of tissue-resident memory T (TRM) cells are associated with better clinical
outcomes in cancer patients. However, the molecular characteristics that drive their efficient …

Immune-checkpoint blockade (ICB) has shown remarkable clinical success in boosting
antitumor immunity. However, the breadth of its cellular targets and specific mode of action …

The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …

Abstract Background Cancer-associated fibroblasts (CAFs) are tumor-promoting and
correlate with poor survival in many cancers, which has led to their emergence as potential …

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia of unknown
cause with a median survival of only three years. Little is known about the mechanisms that …