Integrative structure determination is a powerful approach to modeling the structures of
biological systems based on data produced by multiple experimental and theoretical …

The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …

Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport
between the cytoplasm and nucleoplasm. However, their large size and dynamic nature …

Genome sequencing projects have resulted in a rapid increase in the number of known
protein sequences. In contrast, only about one-hundredth of these sequences have been …

Comparative protein structure modeling predicts the three‐dimensional structure of a given
protein sequence (target) based primarily on its alignment to one or more proteins of known …

Interactions between proteins are orchestrated in a precise and time-dependent manner,
underlying cellular function. The binding affinity, defined as the strength of these …

Structural modeling of macromolecular complexes greatly benefits from interactive
visualization capabilities. Here we present the integration of several modeling tools into …

Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its
regulation. Whereas most RNP enzymes are stable in composition and harbor preformed …

We describe tethered conformation capture (TCC), a method for genome-wide mapping of
chromatin interactions. By performing ligations on solid substrates rather than in solution …

A set of software tools for building and distributing models of macromolecular assemblies
uses an integrative structure modeling approach, which casts the building of models as a …