Small heat shock proteins (sHSPs) are ATP-independent chaperones that delay formation of
harmful protein aggregates. sHSPs' role in protein homeostasis has been appreciated for …

The aggregation of amyloid-β peptide (Aβ) has been linked to the formation of neuritic
plaques, which are pathological hallmarks of Alzheimer's disease (AD). Various natural …

Depending on external conditions, native proteins may change their structure and undergo
different association routes leading to a large scale polymorphism of the aggregates. This …

Alzheimer's disease is associated with the aggregation of amyloid-β (Aβ) peptides into
oligomers and fibrils. We have explored how model lipid membranes modulate the rate and …

Amyloid-β peptide (Aβ) aggregation is one of the hallmarks of Alzheimer's disease (AD).
Mutations in Aβ are associated with early onset familial AD, and the Arctic mutant E22G …

Alzheimer's disease (AD) and Parkinson's disease (PD), including dementia with Lewy
bodies (DLB), account for the majority of dementia cases worldwide. Interestingly, a …

Fluorescent probes thioflavin T (ThT) and 1-anilino-8-naphthalene sulfonate (ANS) are
widely used to study amyloid fibrils that accumulate in the body of patients with serious …

Abstract α‐Synuclein (α‐syn) is an abundant presynaptic protein that is the primary
constituent of inclusions that define Lewy body diseases (LBDs). In these inclusions, α‐syn …

Aggregation and amyloid formation of the 140-residue presynaptic and intrinsically
disordered protein α-synuclein (α-syn) is a pathological hallmark of Parkinson's disease …

Thioflavin-T (ThT) is the most commonly used fluorescent dye for following amyloid
formation semi-quantitatively in vitro, specifically probing the fibrillar cross-β-sheet content …