Controlling translocation through nanopores with fluid wall

M Mayer, E Yusko, J Yang - US Patent 9,347,929, 2016 - Google Patents
Improved resolution and detection of nanoparticles are achieved when a nanopore
connecting liquid compartments in a device running on the Coulter principle is provided with …

Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing …

YA Abassi, N Yu, J Atienza, X Xu, X Wang - US Patent 8,263,375, 2012 - Google Patents
2006-02-02 Assigned to ACEA BIOSCIENCES CORP. reassignment ACEA BIOSCIENCES
CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …

Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments

N Li, X Wang, YA Abassi, B Xi, WF Zhang… - US Patent …, 2017 - Google Patents
(57) ABSTRACT A method of determining one or more beating parameters for use in
cardiomyocyte beating analysis including: providing a cell analysis device including wells …

Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays

YA Abassi, X Wang, X Xu - US Patent 9,399,787, 2016 - Google Patents
(57) ABSTRACT A method of performing an assay of a response of two or more cell types to
a test compound, including: providing a device for monitoring cell-substrate impedance …

Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways

YA Abassi, L Zhao, N Ke, X Wang, X Xu - US Patent 10,215,748, 2019 - Google Patents
Use of impedance devices in methods of generating a time dependent cellular profiles
(TCRP) for the modulation of oncogene addicted cells and comparing the impedance based …

Dynamic monitoring of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) activity and pathways in living cells using real-time microelectronic cell …

YA Abassi, N Yu, J Atienza, X Xu, X Wang - US Patent 10,067,121, 2018 - Google Patents
Use of cell-substrate impedance based methods for screening for agonists of G-Protein
Coupled Receptors (GPCRs) or inhibitors of a Receptor Tyrosine Kinases (RTKs) …

System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or …

X Wang, W Ouyang, N Li, B Xi, YA Abassi… - US Patent …, 2020 - Google Patents
US10551371B2 - System and method for monitoring cardiomyocyte beating, viability and
morphology and for screening for pharmacological agents which may induce cardiotoxicity or …

Biomarker normalization

B Sullivan - US Patent 9,217,702, 2015 - Google Patents
A fluid sample is measured with a tear film measuring system that includes a processing
device that receives a sample chip comprising a sample region configured to contain an …

Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways

YA Abassi, L Zhao, N Ke, X Wang, X Xu - US Patent 10,620,188, 2020 - Google Patents
Methods of identifying whether a biologically active agent affects an oncogene addicted
pathway within a cancer cell, by introducing a biologically active agent suspected of …

Real time electronic cell sensing systems and applications for cell-based assays

X Xu, Y Abassi, X Wang, J Gan - US Patent 9,625,472, 2017 - Google Patents
The present invention includes devices, systems, and meth ods for assaying cells using cell-
substrate impedance moni toring. In one aspect, the invention provides cell-substrate …