The RING finger protein family in health and disease

C Cai, YD Tang, J Zhai, C Zheng - Signal transduction and targeted …, 2022 - nature.com
Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

Early detection of pancreatic cancer using DNA-based molecular approaches

AD Singhi, LD Wood - Nature Reviews Gastroenterology & Hepatology, 2021 - nature.com
Due to its poor prognosis and the late stage at which it is typically diagnosed, early detection
of pancreatic cancer is a pressing clinical problem. Advances in genomic analysis of human …

Integrated genomic characterization of pancreatic ductal adenocarcinoma

BJ Raphael, RH Hruban, AJ Aguirre, RA Moffitt, JJ Yeh… - Cancer cell, 2017 - cell.com
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

[HTML][HTML] Real-time targeted genome profile analysis of pancreatic ductal adenocarcinomas identifies genetic alterations that might be targeted with existing drugs or …

AD Singhi, B George, JR Greenbowe, J Chung, J Suh… - Gastroenterology, 2019 - Elsevier
Background & Aims It has been a challenge to select treatment for patients with pancreatic
ductal adenocarcinomas (PDACs) based on genome alterations. We performed targeted …

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia

AD Singhi, K McGrath, RE Brand, A Khalid, HJ Zeh… - Gut, 2018 - gut.bmj.com
Objective DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the
evaluation of pancreatic cysts (PCs). Mutations in KRAS/GNAS are highly specific for …

Prospective, multi-institutional, real-time next-generation sequencing of pancreatic cyst fluid reveals diverse genomic alterations that improve the clinical management …

A Paniccia, PM Polanco, BA Boone, AI Wald… - Gastroenterology, 2023 - Elsevier
Background & Aims Next-generation sequencing (NGS) of pancreatic cyst fluid is a useful
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …

Comprehensive characterisation of pancreatic ductal adenocarcinoma with microsatellite instability: histology, molecular pathology and clinical implications

C Luchini, LAA Brosens, LD Wood, D Chatterjee… - Gut, 2021 - gut.bmj.com
Objective Recently, tumours with microsatellite instability (MSI)/defective DNA mismatch
repair (dMMR) have gained considerable interest due to the success of immunotherapy in …

Genomic characterization of malignant progression in neoplastic pancreatic cysts

M Noë, N Niknafs, CG Fischer, WM Hackeng… - Nature …, 2020 - nature.com
Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs)
are non-invasive neoplasms that are often observed in association with invasive pancreatic …

[HTML][HTML] Recurrent rearrangements in PRKACA and PRKACB in intraductal oncocytic papillary neoplasms of the pancreas and bile duct

AD Singhi, LD Wood, E Parks, MS Torbenson… - Gastroenterology, 2020 - Elsevier
Background & Aims Intraductal oncocytic papillary neoplasms (IOPNs) of the pancreas and
bile duct contain epithelial cells with numerous, large mitochondria and are cystic precursors …

[HTML][HTML] Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids

L Huang, R Desai, DN Conrad, NC Leite… - Cell Stem Cell, 2021 - cell.com
The exocrine pancreas, consisting of ducts and acini, is the site of origin of pancreatitis and
pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and …