The RING finger protein family in health and disease
C Cai, YD Tang, J Zhai, C Zheng - Signal transduction and targeted …, 2022 - nature.com
Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …
Early detection of pancreatic cancer using DNA-based molecular approaches
Due to its poor prognosis and the late stage at which it is typically diagnosed, early detection
of pancreatic cancer is a pressing clinical problem. Advances in genomic analysis of human …
of pancreatic cancer is a pressing clinical problem. Advances in genomic analysis of human …
Integrated genomic characterization of pancreatic ductal adenocarcinoma
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …
[HTML][HTML] Real-time targeted genome profile analysis of pancreatic ductal adenocarcinomas identifies genetic alterations that might be targeted with existing drugs or …
Background & Aims It has been a challenge to select treatment for patients with pancreatic
ductal adenocarcinomas (PDACs) based on genome alterations. We performed targeted …
ductal adenocarcinomas (PDACs) based on genome alterations. We performed targeted …
Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia
Objective DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the
evaluation of pancreatic cysts (PCs). Mutations in KRAS/GNAS are highly specific for …
evaluation of pancreatic cysts (PCs). Mutations in KRAS/GNAS are highly specific for …
Prospective, multi-institutional, real-time next-generation sequencing of pancreatic cyst fluid reveals diverse genomic alterations that improve the clinical management …
A Paniccia, PM Polanco, BA Boone, AI Wald… - Gastroenterology, 2023 - Elsevier
Background & Aims Next-generation sequencing (NGS) of pancreatic cyst fluid is a useful
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …
Comprehensive characterisation of pancreatic ductal adenocarcinoma with microsatellite instability: histology, molecular pathology and clinical implications
Objective Recently, tumours with microsatellite instability (MSI)/defective DNA mismatch
repair (dMMR) have gained considerable interest due to the success of immunotherapy in …
repair (dMMR) have gained considerable interest due to the success of immunotherapy in …
Genomic characterization of malignant progression in neoplastic pancreatic cysts
Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs)
are non-invasive neoplasms that are often observed in association with invasive pancreatic …
are non-invasive neoplasms that are often observed in association with invasive pancreatic …
[HTML][HTML] Recurrent rearrangements in PRKACA and PRKACB in intraductal oncocytic papillary neoplasms of the pancreas and bile duct
Background & Aims Intraductal oncocytic papillary neoplasms (IOPNs) of the pancreas and
bile duct contain epithelial cells with numerous, large mitochondria and are cystic precursors …
bile duct contain epithelial cells with numerous, large mitochondria and are cystic precursors …
[HTML][HTML] Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
The exocrine pancreas, consisting of ducts and acini, is the site of origin of pancreatitis and
pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and …
pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and …