Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …

Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …

SUMOylation, the covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to
protein substrates, has been reported to suppress type I interferon (IFN1) responses. TAK …

The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …

SUMOylation, as a post-translational modification, plays essential roles in various biological
functions including cell growth, migration, cellular responses to stress and tumorigenesis …

The small ubiquitin-like modifier (SUMO) signaling cascade is critical for gene expression,
genome integrity, and cell cycle progression. In this review, we discuss the important role …

Objective Pancreatic ductal adenocarcinoma (PDAC) has the characteristics of high-density
desmoplastic stroma, a distinctive immunosuppressive microenvironment and is profoundly …

Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark
properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery …

Sumoylation is an essential post-translational modification that has evolved to regulate
intricate networks within emerging complexities of eukaryotic cells. Thousands of target …