The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Recent advances have clarified how the brain detects CO 2 to regulate breathing (central
respiratory chemoreception). These mechanisms are reviewed and their significance is …

Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …

Despite improvements in medical therapy and device‐based treatment, heart failure (HF)
continues to impose enormous burdens on patients and health care systems worldwide …

Neuronal elements distributed throughout the cardiac nervous system, from the level of the
insular cortex to the intrinsic cardiac nervous system, are in constant communication with …

Abstract Study Objectives: Determine the prevalence of central sleep apnea (CSA) in a large
community-based cohort using current definitions and contrast the clinical characteristics of …

We review the substantial recent progress made in understanding the underlying
mechanisms controlling breathing and the applicability of these findings to selected human …

Despite advances in the treatment of heart failure, prognosis is poor, mortality high and there
remains no cure. Heart failure is associated with reduced cardiac pump function, autonomic …

Chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea, enhances
carotid body (CB) chemosensory responses to hypoxia and produces autonomic …

Aims Augmented reflex responses from peripheral chemoreceptors, which are mainly
localized in the carotid bodies (CBs), characterize patients with systolic heart failure and …