[HTML][HTML] CCR5 targeted cell therapy for HIV and prevention of viral escape
G Hütter, J Bodor, S Ledger, M Boyd, M Millington… - Viruses, 2015 - mdpi.com
Allogeneic transplantation with CCR5-delta 32 (CCR5-d32) homozygous stem cells in an
HIV infected individual in 2008, led to a sustained virus control and probably eradication of …
HIV infected individual in 2008, led to a sustained virus control and probably eradication of …
Clinical significance of HIV-1 coreceptor usage
H Schuitemaker, AB van't Wout, P Lusso - Journal of translational …, 2011 - Springer
The identification of phenotypically distinct HIV-1 variants with different prevalence during
the progression of the disease has been one of the earliest discoveries in HIV-1 biology, but …
the progression of the disease has been one of the earliest discoveries in HIV-1 biology, but …
Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues
MJ Churchill, PR Gorry, D Cowley, L Lal… - Journal of …, 2006 - Taylor & Francis
The importance of astrocytes as a reservoir of human immunodeficiency virus type 1 (HIV-1)
in the brain remains elusive. By combining immunohistochemistry, laser capture …
in the brain remains elusive. By combining immunohistochemistry, laser capture …
Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS
Abstract Background CCR5-restricted (R5) human immunodeficiency virus type 1 (HIV-1)
variants cause CD4+ T-cell loss in the majority of individuals who progress to AIDS, but …
variants cause CD4+ T-cell loss in the majority of individuals who progress to AIDS, but …
HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage …
M Roche, MR Jakobsen, J Sterjovski, A Ellett… - Journal of …, 2011 - Am Soc Microbiol
Maraviroc (MVC) inhibits the entry of human immunodeficiency virus type 1 (HIV-1) by
binding to and modifying the conformation of the CCR5 extracellular loops (ECLs) …
binding to and modifying the conformation of the CCR5 extracellular loops (ECLs) …
Host factors and HIV-1 replication: clinical evidence and potential therapeutic approaches
HIV and human defense mechanisms have co-evolved to counteract each other. In the
process of infection, HIV takes advantage of cellular machinery and blocks the action of the …
process of infection, HIV takes advantage of cellular machinery and blocks the action of the …
Prevalence of X4 tropic viruses in patients recently infected with HIV-1 and lack of association with transmission of drug resistance
C de Mendoza, C Rodriguez, F García… - Journal of …, 2007 - academic.oup.com
Background HIV-1 co-receptor usage may play a critical role in AIDS pathogenesis.
Information on viral tropism in HIV-1 seroconverters is scarce, as is the relationship with …
Information on viral tropism in HIV-1 seroconverters is scarce, as is the relationship with …
The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes
LR Gray, G Tachedjian, AM Ellett, MJ Roche… - PloS one, 2013 - journals.plos.org
HIV-1 establishes infection in astrocytes and macroage-lineage cells of the central nervous
system (CNS). Certain antiretroviral drugs (ARVs) can penetrate the CNS, and are therefore …
system (CNS). Certain antiretroviral drugs (ARVs) can penetrate the CNS, and are therefore …
[HTML][HTML] An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes
J Sterjovski, M Roche, MJ Churchill, A Ellett… - Virology, 2010 - Elsevier
While CCR5 is the principal coreceptor used by macrophage (M)-tropic HIV-1, not all
primary CCR5-using (R5) viruses enter macrophages efficiently. Here, we used functionally …
primary CCR5-using (R5) viruses enter macrophages efficiently. Here, we used functionally …
Hyperimmune bovine colostrum as a low-cost, large-scale source of antibodies with broad neutralizing activity for HIV-1 envelope with potential use in microbicides
M Kramski, RJ Center, AK Wheatley… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Bovine colostrum (first milk) contains very high concentrations of IgG, and on average 1 kg
(500 g/liter) of IgG can be harvested from each immunized cow immediately after calving …
(500 g/liter) of IgG can be harvested from each immunized cow immediately after calving …