Monitoring of minimal residual disease (MRD) has become routine clinical practice in
frontline treatment of virtually all childhood acute lymphoblastic leukemia (ALL) and in many …

With rare exceptions, spontaneous tumors originate from a single cell. Yet, at the time of
clinical diagnosis, the majority of human tumors display startling heterogeneity in many …

We profiled adaptive immunity in COVID-19 patients with active infection or after recovery
and created a repository of currently> 14 million B and T cell receptor (BCR and TCR) …

Up to 20% of people worldwide develop gastrointestinal symptoms following a meal, leading
to decreased quality of life, substantial morbidity and high medical costs. Although the …

Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory syndrome
associated with SARS-CoV-2 infection, shares clinical features with toxic shock syndrome …

In principle, humans can produce an antibody response to any non-self-antigen molecule in
the appropriate context. This flexibility is achieved by the presence of a large repertoire of …

Unlimited generation of chimeric antigen receptor (CAR) T cells from human-induced
pluripotent stem cells (iPSCs) is an attractive approach for" off-the-shelf" CAR T cell …

B cells are critical for the production of antibodies and protective immunity to viruses. Here
we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS …

Flow cytometry has become a highly valuable method to monitor minimal residual disease
(MRD) and evaluate the depth of complete response (CR) in bone marrow (BM) of multiple …

Epigenetic studies relied so far on correlations between epigenetic marks and gene
expression pattern. Technologies developed for epigenome editing now enable direct study …