Oxidative stress has been implicated in aging and many human diseases, notably
neurodegenerative disorders and various cancers. The reactive oxygen species that are …

Mitochondria form junctions with the sarco/endoplasmic reticulum (SR/ER), which support
signal transduction and biosynthetic pathways and affect organellar distribution. Recently …

Reactive oxygen species (ROS) are physiological mediators of cellular signaling and play
potentially damaging roles in human diseases. In this study, we found that the catalytic …

S-Glutathionylation is a mechanism of signal transduction by which cells respond effectively
and reversibly to redox inputs. The glutathionylation regulates most cellular pathways. It is …

Inflammatory caspase-11 senses and is activated by intracellular lipopolysaccharide (LPS)
leading to pyroptosis that has critical role in defensing against bacterial infection, whereas …

Plasma membrane forms the barrier between the cytoplasm and the environment. Cells
constantly and selectively transport molecules across their plasma membrane without …

In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has
been reported, along with controversial findings regarding its function. Here, the role of …

Lipid mobilization in adipose tissues, which includes lipogenesis and lipolysis, is a
paramount process in regulating systemic energy metabolism. Reactive oxygen and …

The pseudokinase complement of the human kinase superfamily consists of approximately
60 signaling proteins, which lacks one or more of the amino acids typically required to …

Protein kinases are crucial components of intracellular signaling pathways which transmit
signals by phosphorylation of downstream targets, altering their function. Efficient signal …