Pleiotropy and cross-disorder genetics among psychiatric disorders
Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …
heritability of major psychiatric disorders, established their highly polygenic genetic …
Genes to mental health (G2MH): a framework to map the combined effects of rare and common variants on dimensions of cognition and psychopathology
S Jacquemont, G Huguet, M Klein… - American Journal of …, 2022 - Am Psychiatric Assoc
Rare genomic disorders (RGDs) confer elevated risk for neurodevelopmental psychiatric
disorders. In this era of intense genomics discoveries, the landscape of RGDs is rapidly …
disorders. In this era of intense genomics discoveries, the landscape of RGDs is rapidly …
Genotype–phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID): a case-control cohort …
Background Several copy number variants (CNVs) are associated with a high risk of
neurodevelopmental and psychiatric disorders (referred to as ND-CNVs). We aimed to …
neurodevelopmental and psychiatric disorders (referred to as ND-CNVs). We aimed to …
A neurogenetic model for the study of schizophrenia spectrum disorders: the International 22q11. 2 Deletion Syndrome Brain Behavior Consortium
RE Gur, AS Bassett, DM McDonald-McGinn… - Molecular …, 2017 - nature.com
Rare copy number variants contribute significantly to the risk for schizophrenia, with the
22q11. 2 locus consistently implicated. Individuals with the 22q11. 2 deletion syndrome …
22q11. 2 locus consistently implicated. Individuals with the 22q11. 2 deletion syndrome …
Effects of eight neuropsychiatric copy number variants on human brain structure
Many copy number variants (CNVs) confer risk for the same range of neurodevelopmental
symptoms and psychiatric conditions including autism and schizophrenia. Yet, to date …
symptoms and psychiatric conditions including autism and schizophrenia. Yet, to date …
Social cognition as an RDoC domain
While the bulk of research into neural substrates of behavior and psychopathology has
focused on cognitive, memory and executive functions, there has been a recent surge of …
focused on cognitive, memory and executive functions, there has been a recent surge of …
Comprehensive analysis of a novel mouse model of the 22q11. 2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11. 2 locus
Abstract The 22q11. 2 deletion syndrome (22q11. 2DS) is associated with an increased risk
for psychiatric disorders. Although most of the 22q11. 2DS patients have a 3.0-Mb deletion …
for psychiatric disorders. Although most of the 22q11. 2DS patients have a 3.0-Mb deletion …
Psychosis spectrum features, neurocognition and functioning in a longitudinal study of youth with 22q11. 2 deletion syndrome
BackgroundNeuropsychiatric disorders are common in 22q11. 2 Deletion Syndrome
(22q11DS) with about 25% of affected individuals developing schizophrenia spectrum …
(22q11DS) with about 25% of affected individuals developing schizophrenia spectrum …
Cognitive deficits in childhood, adolescence and adulthood in 22q11. 2 deletion syndrome and association with psychopathology
S Morrison, SJRA Chawner… - Translational …, 2020 - nature.com
Abstract 22q11. 2 Deletion Syndrome (22q11. 2DS) is associated with high risk of
psychiatric disorders and cognitive impairment. It remains unclear to what extent key …
psychiatric disorders and cognitive impairment. It remains unclear to what extent key …
The PHF21B gene is associated with major depression and modulates the stress response
Major depressive disorder (MDD) affects around 350 million people worldwide; however, the
underlying genetic basis remains largely unknown. In this study, we took into account that …
underlying genetic basis remains largely unknown. In this study, we took into account that …