Define chronic post-surgical pain (CPSP) according to the ICD-11 (International
Classification of Diseases, Eleventh Revision) classification and describe its impact on …

This systematic review and meta-analysis aimed at evaluating the role of sleep disturbances
and sleep disorders in influencing presence and intensity of chronic postsurgical pain …

While US opioid prescribing has decreased 38% in the past decade, opioid deaths have
increased 300%. This opioid paradox is poorly recognized. Current approaches to opioid …

From April 2020 through April 2021, 75,673 Americans died from opioid overdoses, nearly
one-quarter of which directly involved prescription opioids. 1 This represents the first time …

Nonsteroidal anti-inflammatory drugs are among the most commonly administered drugs in
the perioperative period due to their prominent role in pain management. However, they …

The randomised controlled trial is the foundation of clinical research; yet there is concern
that many trials have flaws in design, conduct, and reporting that undermine trustworthiness …

Background Chronic postsurgical pain is common after surgery. Identification of non-opioid
analgesics with potential for preventing chronic postsurgical pain is important, although trials …

Chronic pain is a major health problem and the leading cause of years lived with disability.
57 In the absence of disease-modifying therapies and adequate symptomatic treatment …

Regional analgesia failure to prevent CPSP development should prompt us to reconsider its
perioperative utilization. Patients' stratification, for example high-pain responders, might help …

William Morton introduced the world to ether anesthesia for use during surgery in the
Bullfinch Building of the Massachusetts General Hospital on October 16, 1846. For nearly …