The brain requires a continuous supply of energy in the form of ATP, most of which is
produced from glucose by oxidative phosphorylation in mitochondria, complemented by …

Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …

Huntington's disease (HD) is a progressive neurological disease that is inherited in an
autosomal fashion. The cause of disease pathology is an expansion of cytosine-adenine …

Mitochondria play a central role in a plethora of processes related to the maintenance of
cellular homeostasis and genomic integrity. They contribute to preserving the optimal …

Glia, a non-excitable cell type once considered merely as the connective tissue between
neurons, is nowadays acknowledged for its essential contribution to multiple physiological …

Glucose is the universal fuel of most mammalian cells, and it is largely replenished through
dietary intake. Glucose availability to tissues is paramount for the maintenance of …

Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …

Blood brain barrier (BBB) is a group of astrocytes, neurons and endothelial cells, which
makes restricted passage of various biological or chemical entities to the brain tissue. It …