Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

In recent years, there is a growing interest in improving the physicochemical stability of
amorphous pharmaceutical solids due to their very promising applications to manufacture …

We investigated the influence of drug–polymer hydrogen bonding interactions on molecular
mobility and the physical stability in solid dispersions of nifedipine with each of the polymers …

We investigated the correlation between molecular mobility and physical stability in three
model systems, including griseofulvin, nifedipine, and nifedipine–polyvinylpyrrolidone …

The goal was to investigate the correlation between molecular mobility and physical stability
in amorphous itraconazole and identify the specific mobility mode responsible for its …

We investigated a possible correlation between molecular mobility and physical stability in
glassy celecoxib and indomethacin and identified the specific mobility mode responsible for …

Physical instability of amorphous solid dispersions can be a major impediment to their
widespread use. We characterized the molecular mobility in amorphous solid dispersions of …

The amorphous form of a drug usually exhibits higher solubility, faster dissolution rate, and
improved oral bioavailability in comparison to its crystalline forms. However, the amorphous …

We investigated the influence of polymer concentration (2.5–20% w/w) on the molecular
mobility and the physical stability in solid dispersions of nifedipine (NIF) with …

The crystal growth kinetics of amorphous celecoxib (CEL), an anti-inflammatory BCS class II
drug, was systematically investigated for developing effective stabilization strategies to …