Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

The central nervous system (CNS) has the highest concentration of lipids in the organism
after adipose tissue. Among these lipids, the brain is particularly enriched with …

Obesity is one of the worldwide prevalent disease caused by the imbalance between food
intake and energy expenditure. Over a 100 years of research demonstrate that …

Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts
important control on glucose homeostasis, thermogenesis, autonomic nervous system and …

Background The consumption of large amounts of dietary fats is one of the most important
environmental factors contributing to the development of obesity and metabolic disorders …

Abstract Background Interleukin-6 (IL6) produced in the context of exercise acts in the
hypothalamus reducing obesity-associated inflammation and restoring the control of food …

Emerging data demonstrate that microglia activation plays a pivotal role in the development
of hypothalamic inflammation in obesity. Early after the introduction of a high-fat diet …

Although excessive consumption of deep-fried foods is regarded as 1 of the most important
epidemiological factors of lifestyle diseases such as Alzheimer's disease, type 2 diabetes …

Adult stem cells constitute an important reservoir of self-renewing progenitor cells and are
crucial for maintaining tissue and organ homeostasis. The capacity of stem cells to self …

The existence of specific binding sites for benzodiazepines (BZs) in the brain has prompted
the search for endogenous BZ receptor ligands designated by the generic term …