Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

Patients with interstitial lung disease can develop a progressive fibrosing phenotype
characterised by an irreversible, progressive decline in lung function despite treatment …

Cardiac contractility is regulated by several neural, hormonal, paracrine, and autocrine
factors. Amongst these, signaling through β-adrenergic and serotonin receptors generates …

Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides.
While the 11 PDE subfamilies share common features, key differences confer signaling …

Ca2+/calmodulin-dependent protein kinase II (CaMKII) hyperactivity causes cardiac
arrhythmias, a major source of morbidity and mortality worldwide. Despite proven benefits of …

Defects in adipocyte lipolysis drive multiple aspects of cardiometabolic disease, but the
transcriptional framework controlling this process has not been established. To address this …

ABSTRACT Introduction Phosphodiesterase 9 (PDE9) has been demonstrated as a
potential target for neurological disorders and cardiovascular diseases, such as Alzheimer's …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD)
without an identifiable cause. If not treated after diagnosis, the average life expectancy is 3 …

Abstract Cyclic nucleotide phosphodiesterase 9 (PDE9), a specifically hydrolytic enzyme
with the highest affinity for cyclic guanosine monophosphate (cGMP) among the …

Despite advances in the treatment of heart failure in recent years, options for patients are still
limited and the disease is associated with considerable morbidity and mortality. Modulating …