The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications

JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …

[HTML][HTML] Nanotechnology-based antiviral therapeutics

M Chakravarty, A Vora - Drug Delivery and Translational Research, 2021 - Springer
The host immune system is highly compromised in case of viral infections and relapses are
very common. The capacity of the virus to destroy the host cell by liberating its own DNA or …

[HTML][HTML] The versatile heparin in COVID‐19

J Thachil - Journal of Thrombosis and Haemostasis, 2020 - jthjournal.org
Coagulopathy in coronavirus infection has been shown to be associated with high mortality
with high D-dimers being a particularly important marker for the coagulopathy. 1 In the latest …

Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis

BK Tan, S Mainbourg, A Friggeri, L Bertoletti… - Thorax, 2021 - thorax.bmj.com
Background The prevalence of venous thromboembolic event (VTE) and arterial
thromboembolic event (ATE) thromboembolic events in patients with COVID-19 remains …

[HTML][HTML] Exploitation of glycosylation in enveloped virus pathobiology

Y Watanabe, TA Bowden, IA Wilson… - Biochimica et Biophysica …, 2019 - Elsevier
Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …

Heparin as a therapy for COVID-19: current evidence and future possibilities

JA Hippensteel, WB LaRiviere… - … of Physiology-Lung …, 2020 - journals.physiology.org
Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every …

The potential of low molecular weight heparin to mitigate cytokine storm in severe COVID‐19 patients: a retrospective cohort study

C Shi, C Wang, H Wang, C Yang, F Cai… - Clinical and …, 2020 - Wiley Online Library
On March 11, 2020, the World Health Organization declared its assessment of coronavirus
disease 2019 (COVID‐19) as a global pandemic. However, specific anti‐severe acute …

A comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles

TB Gandek, L van der Koog… - Advanced healthcare …, 2023 - Wiley Online Library
A key aspect for successful drug delivery via lipid‐based nanoparticles is their
internalization in target cells. Two prominent examples of such drug delivery systems are …

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

HC Christianson, KJ Svensson… - Proceedings of the …, 2013 - National Acad Sciences
Extracellular vesicle (EV)-mediated intercellular transfer of signaling proteins and nucleic
acids has recently been implicated in the development of cancer and other pathological …

[HTML][HTML] The importance of glycans of viral and host proteins in enveloped virus infection

Y Li, D Liu, Y Wang, W Su, G Liu, W Dong - Frontiers in Immunology, 2021 - frontiersin.org
Animal viruses are parasites of animal cells that have characteristics such as heredity and
replication. Viruses can be divided into non-enveloped and enveloped viruses if a lipid …