Inherited Dysfunction of Sarcoplasmic Reticulum Ca2+ Handling and Arrhythmogenesis
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …
CaMKII in the cardiovascular system: sensing redox states
JR Erickson, BJ He, IM Grumbach… - Physiological …, 2011 - journals.physiology.org
The multifunctional Ca2+-and calmodulin-dependent protein kinase II (CaMKII) is now
recognized to play a central role in pathological events in the cardiovascular system. CaMKII …
recognized to play a central role in pathological events in the cardiovascular system. CaMKII …
[PDF][PDF] So little source, so much sink: requirements for afterdepolarizations to propagate in tissue
How early (EADs) and delayed afterdepolarizations (DADs) overcome electrotonic source-
sink mismatches in tissue to trigger premature ventricular complexes remains incompletely …
sink mismatches in tissue to trigger premature ventricular complexes remains incompletely …
The Role of Late I Na in Development of Cardiac Arrhythmias
C Antzelevitch, V Nesterenko, JC Shryock… - Voltage gated sodium …, 2014 - Springer
Late I Na is an integral part of the sodium current, which persists long after the fast-
inactivating component. The magnitude of the late I Na is relatively small in all species and …
inactivating component. The magnitude of the late I Na is relatively small in all species and …
Na+ transport in the normal and failing heart—remember the balance
S Despa, DM Bers - Journal of molecular and cellular cardiology, 2013 - Elsevier
In the heart, intracellular Na+ concentration ([Na+] i) is a key modulator of Ca 2+ cycling,
contractility and cardiac myocyte metabolism. Several Na+ transporters are electrogenic …
contractility and cardiac myocyte metabolism. Several Na+ transporters are electrogenic …
The arrhythmogenic consequences of increasing late INa in the cardiomyocyte
JC Shryock, Y Song, S Rajamani… - Cardiovascular …, 2013 - academic.oup.com
This review presents the roles of cardiac sodium channel NaV1. 5 late current (late I Na) in
generation of arrhythmic activity. The assumption of the authors is that proper Na+ channel …
generation of arrhythmic activity. The assumption of the authors is that proper Na+ channel …
[HTML][HTML] The Purkinje–myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT
DJ Blackwell, M Faggioni, MJ Wleklinski… - JCI insight, 2022 - ncbi.nlm.nih.gov
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome
caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking …
caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking …
Targeted Sarcoplasmic Reticulum Ca2+ ATPase 2a Gene Delivery to Restore Electrical Stability in the Failing Heart
MJ Cutler, X Wan, BN Plummer, H Liu, I Deschenes… - Circulation, 2012 - Am Heart Assoc
Background—Recently, we reported that sarcoplasmic reticulum Ca2+ ATPase 2a
(SERCA2a), the pump responsible for reuptake of cytosolic calcium during diastole, plays a …
(SERCA2a), the pump responsible for reuptake of cytosolic calcium during diastole, plays a …
Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes
In this review article we give an overview of current knowledge with respect to redox-
sensitive alterations in Na+ and Ca 2+ handling in the heart. In particular, we focus on redox …
sensitive alterations in Na+ and Ca 2+ handling in the heart. In particular, we focus on redox …
Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissue
Background Delayed afterdepolarizations (DADs) have been well characterized as
arrhythmia triggers, but their role in generating a tissue substrate vulnerable to reentry is not …
arrhythmia triggers, but their role in generating a tissue substrate vulnerable to reentry is not …