The emergence and worldwide spread of drug‐resistant bacteria have already posed a
serious threat to human life, creating the urgent need to develop potent and novel …

C3-fluorinated oxindoles are important scaffolds known to demonstrate various biological
properties. As the bio-isosteres of oxindoles, these compounds have shown tremendous …

Parasitic nematodes are a major threat to global food security, particularly as the world
amasses 10 billion people amid limited arable land,,–. Most traditional nematicides have …

The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive
molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors …

Herein, a solvent-free synthesis of 5-bromothiophene based 3, 4-dihydropyrimidin-2-(1 H)-
(thi) ones was explored. The main advantages of this study are that pure products are …

Imidazopyridine is an important framework that constitutes several pharmaceutical drugs
and biologically active molecules. Herein, we present the palladium-catalyzed …

A powerful analgesic, anti-inflammatory and antimicrobial drug was developed by
synthesizing a set of new indole-2, 3-dione derivatives. The chemical structures of the …

A visible light induced hydrodifluoromethylation of alkenes derived from oxindoles with
(difluoromethyl) triphenylphosphonium bromide was developed. This reaction delivers a …

An efficient and regioselective synthesis of novel 4‐aryl‐2‐methyl‐N‐phenacylimidazoles 5
by a microwave‐assisted pseudo‐tricomponent reaction between acetamidine …

Appertaining to its paracrine and autocrine signaling loops, VEGFR-2 succeeded in
grabbing attention as one of the leading targets in cancer treatment. Based on the foregoing …