Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Exosome-derived microRNAs of human milk and their effects on infant health and development

BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the …

C Théry, KW Witwer, E Aikawa… - Journal of …, 2018 - Wiley Online Library
The last decade has seen a sharp increase in the number of scientific publications
describing physiological and pathological functions of extracellular vesicles (EVs), a …

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

KW Witwer, EI Buzás, LT Bemis, A Bora… - Journal of …, 2013 - Taylor & Francis
The emergence of publications on extracellular RNA (exRNA) and extracellular vesicles
(EV) has highlighted the potential of these molecules and vehicles as biomarkers of disease …

MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells

IS Okoye, SM Coomes, VS Pelly, S Czieso… - Immunity, 2014 - cell.com
Summary Foxp3+ T regulatory (Treg) cells prevent inflammatory disease but the mechanistic
basis of suppression is not understood completely. Gene silencing by RNA interference can …

Emerging role of extracellular vesicles in inflammatory diseases

EI Buzas, B György, G Nagy, A Falus… - Nature Reviews …, 2014 - nature.com
The discovery that submicron-sized extracellular vesicles (EVs) are generated by both
prokaryotic and eukaryotic cells might have a profound effect on experimental and clinical …

Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis

S Ju, J Mu, T Dokland, X Zhuang, Q Wang, H Jiang… - Molecular Therapy, 2013 - cell.com
Food-derived exosome-like nanoparticles pass through the intestinal tract throughout our
lives, but little is known about their impact or function. Here, as a proof of concept, we show …

Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain

X Zhuang, X Xiang, W Grizzle, D Sun, S Zhang… - Molecular Therapy, 2011 - cell.com
In this study, exosomes used to encapsulate curcumin (Exo-cur) or a signal transducer and
activator of transcription 3 (Stat3) inhibitor, ie, JSI124 (Exo-JSI124) were delivered …

Membrane vesicles as conveyors of immune responses

C Théry, M Ostrowski, E Segura - Nature reviews immunology, 2009 - nature.com
In multicellular organisms, communication between cells mainly involves the secretion of
proteins that then bind to receptors on neighbouring cells. But another mode of intercellular …

Cancer exosomes trigger fibroblast to myofibroblast differentiation

J Webber, R Steadman, MD Mason, Z Tabi, A Clayton - Cancer research, 2010 - AACR
There is a growing interest in the cell–cell communication roles in cancer mediated by
secreted vesicles termed exosomes. In this study, we examined whether exosomes …