Conspectus The six-membered heterocycles containing oxygen and nitrogen
(tetrahydropyrans, pyrans, piperidines) are among the most common heterocyclic structures …

Electricity originating from renewable resources can be used for highly sustainable and
economically attractive applications. With electrons as the mass-free reagent, the use of a …

Pyrroloindolines are important and privileged polycyclic indoline motifs that are widely
present in natural products and bio-significant molecules. From an organic chemistry …

We report the use of electrochemistry to perform a direct oxidative dearomatization of
indoles leading to 2, 3-dialkoxy or 2, 3-diazido indolines under undivided conditions at a …

Oxidation of indoles is a fundamental organic transformation to deliver a variety of
synthetically and pharmaceutically valuable nitrogen-containing compounds. Prior methods …

Reported is a new green protocol for the efficient in situ generation of nitrile oxides through
NaCl/Oxone oxidation of aldoximes and their dipolar cycloaddition. The key feature is the …

The Hofmann and Curtius rearrangements have been widely used in organic synthesis and
developed for the industrial production (5–100 kg) of pharmaceutically relevant …

Due to the electron-richness of the C3/C2 positions of the indole moiety, direct nucleophilic
bromination at the C5-position of tryptophol and tryptamine derivatives is difficult and …

We developed performant in situ hypohalite, especially hypobromite, catalysis for the
oxidative dearomatization of low-reactivity electron-deficient arenols. The reaction scope …

Nitrile imines are highly reactive and versatile dipoles and conventionally generated in situ
from unstable hydrazonyl halides under basic conditions. Herein, we report the first green …