Abstract Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and
function of the previously 'invisible'parts of the genome and allow comparative analyses of …

Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

Cancers and developmental disorders are associated with alterations in the 3D genome
architecture in space and time (the fourth dimension). Mammalian 3D genome organization …

Chromatin domains and loops are important elements of chromatin structure and dynamics,
but much remains to be learned about their exact biological role and nature. Topological …

Vertebrate genomes organize into topologically associating domains, delimited by
boundaries that insulate regulatory elements from nontarget genes. However, how boundary …

Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular
response to stress. However, the molecular mechanisms by which p53 controls gene …

Nucleosomes represent hubs in chromatin organization and gene regulation and interact
with a plethora of chromatin factors through different modes. In addition, alterations in …

Background The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in
adult muscle satellite cells (SCs) within hours following muscle damage and is required for …

Activation of regeneration upon tissue damages requires the activation of many
developmental genes responsible for cell proliferation, migration, differentiation, and tissue …

Since 2005, thousands of genome-wide association studies (GWAS) have been published,
identifying hundreds of thousands of genetic variants that increase risk of complex traits …