In-vitro models of disc degeneration–A review of methods and clinical relevance

EDR Tapia, JR Meakin, TP Holsgrove - Journal of Biomechanics, 2022 - Elsevier
The intervertebral disc (IVD) provides flexibility, acts as a shock absorber, and transmits
load. Degeneration of the IVD includes alterations in the biomechanics, extracellular matrix …

Integrating MRI-based geometry, composition and fiber architecture in a finite element model of the human intervertebral disc

MA Stadelmann, G Maquer, B Voumard, A Grant… - Journal of the …, 2018 - Elsevier
Intervertebral disc degeneration is a common disease that is often related to impaired
mechanical function, herniations and chronic back pain. The degenerative process induces …

[HTML][HTML] The influence of geometry on intervertebral disc stiffness

S Tavana, C Shek, T Rahman, N Baxan… - Journal of Biomechanics, 2024 - Elsevier
Geometry plays an important role in intervertebral disc (IVD) mechanics. Previous
computational studies have found a link between IVD geometry and stiffness. However, few …

Differences in IVD characteristics between low back pain patients and controls associated with HIZ as revealed with quantitative MRI

C Waldenberg, H Hebelka, H Brisby, KM Lagerstrand - PLoS One, 2019 - journals.plos.org
Background Magnetic resonance imaging (MRI) can provide objective continuous
intervertebral disc (IVD) measures in low back pain (LBP) patients. However, there are …

Lumbar annulus fibrosus biomechanical characterization in healthy children by ultrasound shear wave elastography

C Vergari, G Dubois, R Vialle, JL Gennisson… - European …, 2016 - Springer
Objectives Intervertebral disc (IVD) is key to spine biomechanics, and it is often involved in
the cascade leading to spinal deformities such as idiopathic scoliosis, especially during the …

Axial loading during MRI influences T2-mapping values of lumbar discs: a feasibility study on patients with low back pain

M Nilsson, K Lagerstrand, I Kasperska, H Brisby… - European Spine …, 2016 - Springer
Purpose To investigate whether axial loading of the spine during MRI (alMRI)
instantaneously induces changes in biochemical disc features as reflected by altered …

Finite element analysis predicts experimental failure patterns in vertebral bodies loaded via intervertebral discs up to large deformation

AL Clouthier, HS Hosseini, G Maquer… - Medical engineering & …, 2015 - Elsevier
Vertebral compression fractures are becoming increasingly common. Patient-specific
nonlinear finite element (FE) models have shown promise in predicting yield strength and …

Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent …

Y Lu, G Maquer, O Museyko, K Püschel, K Engelke… - Journal of …, 2014 - Elsevier
Quantitative computer tomography (QCT)-based finite element (FE) models of vertebral body
provide better prediction of vertebral strength than dual energy X-ray absorptiometry …

Axial loading during MRI reveals deviant characteristics within posterior IVD regions between low back pain patients and controls

H Hebelka, L Torén, K Lagerstrand, H Brisby - European Spine Journal, 2018 - Springer
Purpose To investigate differences in functional intervertebral disk (IVD) characteristics
between low back pain (LBP) patients and controls using T2-mapping with axial loading …

Compressive strength of elderly vertebrae is reduced by disc degeneration and additional flexion

G Maquer, J Schwiedrzik, G Huber, MM Morlock… - Journal of the …, 2015 - Elsevier
Computer tomography (CT)-based finite element (FE) models assess vertebral strength
better than dual energy X-ray absorptiometry. Osteoporotic vertebrae are usually loaded via …