Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …

Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Recent investigations have yielded both profound insights into the mechanisms required by
pathogenic fungi for virulence within the human host, as well as novel potential targets for …

Hsp90 is a molecular chaperone for many signal transducers and may influence evolution
by releasing previously silent genetic variation in response to environmental change. In …

Invasive fungal infections are an important cause of human mortality and morbidity,
particularly for immunocompromised populations. However, there remains a paucity of …

The emergence of drug resistance in pathogenic microorganisms provides an excellent
example of microbial evolution that has had profound consequences for human health. The …

The survival of all organisms depends critically upon interactions with the environment,
mediated largely through the action of small molecules. Small molecules can provide the …

The persistence of high morbidity and mortality from systemic fungal infections despite the
availability of novel antifungals points to the need for effective treatment strategies …

The number of immunocompromised patients with invasive fungal infections continues to
increase and new antifungal therapies are not keeping pace with the growing incidence of …