The valproic acid-induced rodent model of autism

C Nicolini, M Fahnestock - Experimental neurology, 2018 - Elsevier
Autism is a lifelong neurodevelopmental disorder characterized by impairments in social
communication and interaction and by repetitive patterns of behavior, interests and activities …

Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy

T Tomson, D Battino, R Bromley, S Kochen… - Epileptic …, 2019 - shs.cairn.info
Management of epilepsy in pregnancy: a report from the International League Against Epilepsy
Task Force on Women and Pregnancy | Cairn.info Cairn.info, Matières à réflexion Cairn.info …

Valproic acid and epilepsy: from molecular mechanisms to clinical evidences

M Romoli, P Mazzocchetti, R D'Alonzo… - Current …, 2019 - ingentaconnect.com
After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

Adverse effects of antiepileptic drugs

P Perucca, FG Gilliam - The lancet neurology, 2012 - thelancet.com
More than 150 years after bromide was introduced as the first antiepileptic drug, adverse
effects remain a leading cause of treatment failure and a major determinant of impaired …

The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs

RL Bromley, GE Mawer, M Briggs, C Cheyne… - Journal of Neurology …, 2013 - jnnp.bmj.com
The aim of this study was to compare the prevalence of diagnosed neurodevelopmental
disorders in children exposed, in utero, to different antiepileptic drug treatments. A …

Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug

T Tomson, D Battino, E Perucca - The Lancet Neurology, 2016 - thelancet.com
Since the serendipitous discovery of its anticonvulsant properties more than 50 years ago,
valproic acid has become established as an effective broad-spectrum antiepileptic drug that …

IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study

GA Baker, RL Bromley, M Briggs, CP Cheyne… - Neurology, 2015 - AAN Enterprises
Objective: To delineate the risk to child IQ associated with frequently prescribed antiepileptic
drugs. Methods: Children born to women with epilepsy (n= 243) and women without …

Adverse drug reactions induced by valproic acid

RM Nanau, MG Neuman - Clinical biochemistry, 2013 - Elsevier
Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly
in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic …

Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child

R Bromley, J Weston, N Adab… - Cochrane Database …, 2014 - cochranelibrary.com
Background Accumulating evidence suggests an association between prenatal exposure to
antiepileptic drugs (AEDs) and increased risk of both physical anomalies and …

Teratogenic effects of antiepileptic drugs

T Tomson, D Battino - The Lancet Neurology, 2012 - thelancet.com
Most women with active epilepsy need treatment with antiepileptic drugs during pregnancy.
Antiepileptic drugs are also frequently used for other indications, such as migraine, pain …