Myelodysplastic Syndromes MDS are clonal hematopoietic disorders involving morphologic
defects and peripheral-blood cytopenias, with a risk of progression to acute myeloid …

Updating the classification of hematologic neoplasia with germline predisposition, pediatric
myelodysplastic syndrome (MDS), and juvenile myelomonocytic leukemia (JMML) is critical …

To understand the mechanisms that mediate germline genetic leukemia predisposition, we
studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone …

Shwachman-Diamond syndrome (SDS) is an inherited multisystem ribosomopathy
characterized by exocrine pancreatic deficiency, bone marrow failure, and predisposition to …

Shwachman-Diamond syndrome is a rare inherited bone marrow failure syndrome
characterized by neutropenia, exocrine pancreatic insufficiency, and skeletal abnormalities …

The role of allogeneic hematopoietic stem cell transplantation (HCT) in the treatment of
acute myelogenous leukemia (AML) in children is reviewed and critically evaluated in this …

Shwachman-Diamond syndrome (SDS) is an inherited bone marrow failure syndrome with
leukemia predisposition. An understanding of the hematologic complications of SDS with …

Biallelic germ line excision repair cross-complementing 6 like 2 (ERCC6L2) variants
strongly predispose to bone marrow failure (BMF) and myeloid malignancies, characterized …

The recent application of whole exome or whole genome sequencing unveiled a plethora of
germline variants predisposing to myeloid disorders, particularly myelodysplastic …

Pediatric myelodysplastic syndromes (MDS) often raise concern for an underlying germline
predisposition to hematologic malignancies, referred to as germline predisposition herein …