The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …

In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in
life. This observation resulted in a sea-change in how researchers viewed aging. This was …

Rapamycin (sirolimus) is a macrolide immunosuppressant that inhibits the mechanistic
target of rapamycin (mTOR) protein kinase and extends lifespan in model organisms …

The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …

An emerging role for the circadian clock in autophagy and lysosome function has opened
new avenues for exploration in the field of neurodegeneration. The daily rhythms of …

The circadian clock coordinates physiology and metabolism. mTOR (mammalian/
mechanistic target of rapamycin) is a major intracellular sensor that integrates nutrient and …

Most living beings, including humans, must adapt to rhythmically occurring daily changes in
their environment that are generated by the E arth's rotation. In the course of evolution, these …

Diurnal oscillations of gene expression are a hallmark of rhythmic physiology across most
living organisms. Such oscillations are controlled by the interplay between the circadian …