Abstract Treatment of high-grade serous ovarian cancer (HGSOC) remains challenging.
Although HGSOC can potentially be responsive to immunotherapy owing to endogenous …

Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional
repression and chromatin condensation mechanisms by removing the acetyl moiety from …

The present review aims to explore the potential targets/partners for future targeted
radionuclide therapy (TRT) strategies, wherein cancer cells often are not killed effectively …

Background Distant metastasis remains the leading cause of treatment failure in patients
with nasopharyngeal carcinoma (NPC), making it critical to identify efficient therapeutic …

Background Although immune checkpoint inhibitors (ICIs) have influenced the treatment
paradigm for multiple solid tumors, increasing evidence suggests that primary and adaptive …

Simple Summary The natural compound sulforaphane is highly popular among tumor
patients, since it is suggested to prevent oncogenesis and cancer progression. However …

Background The intensive interplay between aberrant epigenetic events and metabolic
remodeling represents one of the hallmarks of tumors, including colon cancer. The functions …

SMARCA4-deficient undifferentiated thoracic tumor is extremely invasive. This tumor with
poor prognosis is easily confused with SMARCA4-deficent non-small cell lung cancer or …

Sarcoma is a rare and heterogeneous class of mesenchymal malignancies with poor
prognosis. Panobinostat (LBH589) as one of histone deacetylase (HDAC) inhibitors has …

Exhaustion is a state of CD8 T cell differentiation that occurs in settings of chronic Ag such
as tumors, chronic viral infection, and autoimmunity. Cellular differentiation is driven by a …