Cancer stem cells (CSCs) have important roles in tumour development, relapse and
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …

The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell
proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in …

Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …

An essential role for Hedgehog (Hh) signaling in human cancer has been established
beyond doubt. At present, targeting Hh signaling has mainly been investigated with SMO …

The epithelial-to-mesenchymal transition (EMT) is a reversible process comprised of various
subprograms via which epithelial cells reduce their intercellular adhesions and proliferative …

Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman
Effect, is due to altered use of methionine for increased and aberrant transmethylation …

Basal cell carcinoma (BCC) is the most commonly diagnosed skin cancer worldwide. In most
patients, BCC can be effectively treated with standard surgical excision, Mohs micrographic …

Basal cell carcinoma (BCC) of the skin is driven by aberrant hedgehog signaling. Thus
blocking this signaling pathway by small molecules such as vismodegib inhibits tumor …

The hedgehog pathway, for which sonic hedgehog (Shh) is the most prominent ligand, is
highly conserved and is tightly associated with embryonic development in a number of …

Abstract Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been
implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF …