Corticosteroids: mechanisms of action in health and disease

S Ramamoorthy, JA Cidlowski - Rheumatic Disease …, 2016 - rheumatic.theclinics.com
Corticosteroids are a class of steroid hormones released by the adrenal cortex, which
includes glucocorticoids and mineralocorticoids. 1 However, the term “corticosteroids” is …

The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease

RH Oakley, JA Cidlowski - Journal of Allergy and Clinical Immunology, 2013 - Elsevier
Glucocorticoids are primary stress hormones necessary for life that regulate numerous
physiologic processes in an effort to maintain homeostasis. Synthetic derivatives of these …

Glucocorticoid receptor signaling in health and disease

M Kadmiel, JA Cidlowski - Trends in pharmacological sciences, 2013 - cell.com
Glucocorticoids are steroid hormones regulated in a circadian and stress-associated
manner to maintain various metabolic and homeostatic functions that are necessary for life …

Skeletal biology and disease modeling in zebrafish

K Dietrich, IAK Fiedler, A Kurzyukova… - Journal of Bone and …, 2020 - academic.oup.com
Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Modeling inflammation in zebrafish for the development of anti-inflammatory drugs

Y Xie, AH Meijer, MJM Schaaf - Frontiers in cell and developmental …, 2021 - frontiersin.org
Dysregulation of the inflammatory response in humans can lead to various inflammatory
diseases, like asthma and rheumatoid arthritis. The innate branch of the immune system …

Organochlorine pesticides: Agrochemicals with potent endocrine-disrupting properties in fish

CJ Martyniuk, AC Mehinto, ND Denslow - Molecular and cellular …, 2020 - Elsevier
Organochlorine pesticides (OCPs) are persistent environmental contaminants that act as
endocrine disruptors and organ system toxicants. These pesticides (eg …

Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids

RH Oakley, JA Cidlowski - Journal of Biological Chemistry, 2011 - ASBMB
Glucocorticoids regulate numerous physiological processes and are mainstays in the
treatment of inflammation, autoimmune disease, and cancer. The traditional view that …

Steroids in teleost fishes: A functional point of view

J Tokarz, G Möller, MH de Angelis, J Adamski - Steroids, 2015 - Elsevier
Steroid hormones are involved in the regulation of a variety of processes like embryonic
development, sex differentiation, metabolism, immune responses, circadian rhythms, stress …

Zebrafish embryos and larvae: a new generation of disease models and drug screens

S Ali, DL Champagne, HP Spaink… - … Research Part C …, 2011 - Wiley Online Library
Technological innovation has helped the zebrafish embryo gain ground as a disease model
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …

Molecular psychiatry of zebrafish

AM Stewart, JFP Ullmann, WHJ Norton, MO Parker… - Molecular …, 2015 - nature.com
Due to their well-characterized neural development and high genetic homology to
mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field …