Single-cell proteomics workflows have considerably improved in sensitivity and
reproducibility to characterize as-yet unknown biological phenomena. With the emergence …

Single‐cell technologies have revolutionized research in the last decade, including for skin
biology. Single‐cell RNA sequencing has emerged as a powerful tool allowing the …

Single‐cell proteomics aims to characterize biological function and heterogeneity at the
level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput …

Global quantification of protein abundances in single cells could provide direct information
on cellular phenotypes and complement transcriptomics measurements. However, single …

Background Many biological processes, such as cell division cycle and drug resistance, are
reflected in protein covariation across single cells. This covariation can be quantified and …

Single-cell proteomics (scProteomics) promises to advance our understanding of cell
functions within complex biological systems. However, a major challenge of current methods …

Single-cell proteomics (SCP) can provide information that is unattainable through either bulk-
scale protein measurements or single-cell profiling of other omes. Maximizing proteome …

In the young field of single-cell proteomics (scMS), there is a great need for improved global
proteome characterization, both in terms of proteins quantified per cell and quantitative …

Multiplexing approaches using tandem mass tags with a carrier proteome to boost sensitivity
have advanced single cell proteomics by mass spectrometry (SCoPE-MS). Here, we probe …

Single cell proteomics is a powerful tool with potential for markedly enhancing
understanding of cellular processes. Here we report the development and application of …