A large portion of research in the social sciences is devoted to using interventions to combat
societal and social problems, such as prejudice, discrimination, and intergroup conflict …

Master protocol, categorized as basket trial, umbrella trial or platform trial, is an innovative
clinical trial framework that aims to expedite clinical drug development, enhance trial …

Background For medical conditions with numerous interventions worthy of investigation,
there are many advantages of a multi-arm multi-stage (MAMS) platform trial approach …

When multiple hypothesis tests are conducted, the familywise Type I error probability
correspondingly increases. Various multiple test procedures (MTPs) have been developed …

One of the challenges in bringing new therapeutic agents (since nimodipine) in for the
treatment of cerebral ischemia associated with aneurysmal subarachnoid hemorrhage …

Platform trials evaluate multiple experimental treatments under a single master protocol,
where new treatment arms are added to the trial over time. Given the multiple treatment …

Multi-arm, parallel-group clinical trials are an efficient way of testing several new treatments,
treatment regimens or doses. However, guidance on the requirement for statistical …

When testing multiple hypotheses, a suitable error rate should be controlled even in
exploratory trials. Conventional methods to control the False Discovery Rate assume that all …

For the development of coronavirus disease 2019 (COVID‐19) drugs during the ongoing
pandemic, speed is of essence whereas quality of evidence is of paramount importance …

Platform trials have become increasingly popular for drug development programs, attracting
interest from statisticians, clinicians and regulatory agencies. Many statistical questions …