Replication stress is a major cause of genomic instability and a crucial vulnerability of
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …

The shortening of human telomeres has two opposing effects during cancer development.
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …

Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …

Telomeres are nucleoprotein structures that cap the end of each chromosome arm and
function to maintain genome stability. The length of telomeres is known to shorten with each …

Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …

Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Telomerase is a key enzyme for cell survival that prevents telomere shortening and the
subsequent cellular senescence that is observed after many rounds of cell division. In …

Alternative lengthening of telomeres (ALT) is a telomerase-independent but recombination-
dependent pathway that maintains telomeres. Here, we describe an assay to visualize ALT …

Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic
mechanisms responsible for telomere maintenance in tumors have only recently been …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …