Cartilage regeneration and repair remain a clinical challenge due to the limited capability of
cartilage to self-regenerate. Worldwide, the costs associated with cartilage regeneration per …

Negatively charged tissues are ubiquitous in the human body and are associated with a
number of common diseases yet remain an outstanding challenge for targeted drug delivery …

Cartilage is a tension-and load-bearing tissue and has a limited capacity for intrinsic self-
healing. While microfracture and arthroplasty are the conventional methods for cartilage …

Articular cartilage is composed of chondrons within a territorial matrix surrounded by a
highly organized extracellular matrix comprising collagen II fibrils, proteoglycans …

The use of tissue-engineered articular cartilage (TEAC) constructs has the potential to
become a powerful treatment option for cartilage lesions resulting from trauma or early …

Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …

Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering
approaches are primarily based on collagen type I devices that are associated with …

Traditional farm‐based products based on livestock are one of the main contributors to
greenhouse gas emissions. Cultivated meat is an alternative that mimics animal meat, being …

Adding chondroitin sulfate (CS) to collagen scaffolds has been shown to improve the
outcomes for articular cartilage tissue engineering. Instead of physical entrapment or …

Glycosaminoglycans (GAGs) are heterogeneous acidic polysaccharides involved in a range
of biological functions. They have a significant influence on the regulation of cellular …