Clinical management of HIV drug resistance
KJ Cortez, F Maldarelli - Viruses, 2011 - mdpi.com
Combination antiretroviral therapy for HIV-1 infection has resulted in profound reductions in
viremia and is associated with marked improvements in morbidity and mortality. Therapy is …
viremia and is associated with marked improvements in morbidity and mortality. Therapy is …
Minority variants of drug-resistant HIV
S Gianella, DD Richman - The Journal of infectious diseases, 2010 - academic.oup.com
Minor drug-resistant variants exist in every patient infected with human immunodeficiency
virus (HIV). Because these minority variants are usually present at very low levels, they …
virus (HIV). Because these minority variants are usually present at very low levels, they …
Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral use
Background It is largely unknown how frequently low-abundance HIV drug-resistant variants
at levels under limit of detection of conventional genotyping (< 20% of quasi-species) are …
at levels under limit of detection of conventional genotyping (< 20% of quasi-species) are …
Sensitive deep-sequencing-based HIV-1 genotyping assay to simultaneously determine susceptibility to protease, reverse transcriptase, integrase, and maturation …
With 29 individual antiretroviral drugs available from six classes that are approved for the
treatment of HIV-1 infection, a combination of different phenotypic and genotypic tests is …
treatment of HIV-1 infection, a combination of different phenotypic and genotypic tests is …
Attenuators
JM Yeakley, B Seligmann, J McComb - US Patent 9,957,550, 2018 - Google Patents
US9957550B2 - Attenuators - Google Patents US9957550B2 - Attenuators - Google Patents
Attenuators Download PDF Info Publication number US9957550B2 US9957550B2 US14/480,525 …
Attenuators Download PDF Info Publication number US9957550B2 US9957550B2 US14/480,525 …
HIV-1 resistance to maraviroc conferred by a CD4 binding site mutation in the envelope glycoprotein gp120
Maraviroc (MVC) is a CCR5 antagonist that inhibits HIV-1 entry by binding to the coreceptor
and inducing structural alterations in the extracellular loops. In this study, we isolated MVC …
and inducing structural alterations in the extracellular loops. In this study, we isolated MVC …
Presence, persistence and effects of pre-treatment HIV-1 drug resistance variants detected using next generation sequencing: A Retrospective longitudinal study from …
AS Hassan, DF Bibby, SM Mwaringa, CA Agutu… - PloS one, 2019 - journals.plos.org
Background The epidemiology of HIV-1 drug resistance (HIVDR) determined by Sanger
capillary sequencing, has been widely studied. However, much less is known about HIVDR …
capillary sequencing, has been widely studied. However, much less is known about HIVDR …
Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors
Natural evolution in primate lentiviral reverse transcriptase (RT) appears to have been
constrained by the necessity to maintain function within an asymmetric protein composed of …
constrained by the necessity to maintain function within an asymmetric protein composed of …
Transmitted HIV resistance to first-line antiretroviral therapy in Lima, Peru
J Soria, M Bull, C Mitchell, A La Rosa… - AIDS research and …, 2012 - liebertpub.com
Transmission of drug-resistant HIV (TDR) has been associated with virologic failure of “first-
line,” nonnucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy …
line,” nonnucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy …
Covering all bases in HIV research: unveiling a hidden world of viral evolution.
The advent of next-generation sequencing technologies has greatly impacted genomic
research by providing a means for increasing the amount of sequence information in a cost …
research by providing a means for increasing the amount of sequence information in a cost …