Traumatic brain injuries: pathophysiology and potential therapeutic targets
SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …
amongst civilians and military personnel globally. Despite advances in our knowledge of the …
Effects of mesenchymal stem cell-derived exosomes on autoimmune diseases
Recent years, the immunosuppressive properties of mesenchymal stem cells (MSCs) have
been demonstrated in preclinical studies and trials of inflammatory and autoimmune …
been demonstrated in preclinical studies and trials of inflammatory and autoimmune …
Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT …
W Liu, M Yu, D Xie, L Wang, C Ye, Q Zhu, F Liu… - Stem cell research & …, 2020 - Springer
Background After surgery, wound recovery in diabetic patients may be disrupted due to
delayed inflammation, which can lead to undesired consequences, and there is currently a …
delayed inflammation, which can lead to undesired consequences, and there is currently a …
Intravascular mesenchymal stromal/stem cell therapy product diversification: time for new clinical guidelines
Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …
MSC exosome works through a protein-based mechanism of action
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …
Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …
MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …
animal and clinical studies. The efficacy of MSC-based therapies which was previously …
MSC-derived extracellular vesicles attenuate immune responses in two autoimmune murine models: type 1 diabetes and uveoretinitis
Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal
stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We …
stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We …
Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells
J Leibacher, R Henschler - Stem cell research & therapy, 2016 - Springer
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied
cellular therapeutic. They were found to be potent in situations such as tissue repair or …
cellular therapeutic. They were found to be potent in situations such as tissue repair or …
Systemic administration of exosomes released from mesenchymal stromal cells attenuates apoptosis, inflammation, and promotes angiogenesis after spinal cord …
JH Huang, XM Yin, Y Xu, CC Xu, X Lin, FB Ye… - Journal of …, 2017 - liebertpub.com
Spinal cord injury (SCI) is one of the most common devastating injuries, which causes
permanent disabilities such as paralysis and loss of movement or sensation. The precise …
permanent disabilities such as paralysis and loss of movement or sensation. The precise …