Antibodies develop to varying degrees during treatment with human proteins, including
insulin, growth hormone, granulocyte-macrophage colony-stimulating factor, factor VIII …

Lysosomal storage diseases are characterized by deficiencies in lysosomal enzymes,
allowing accumulation of target substrate in cells and eventually causing cell death. Enzyme …

Autoantibody-mediated tissue destruction is among the main features of organ-specific
autoimmunity. This report describes “an antibody enzyme”(abzyme) contribution to the site …

The development of inhibitory 'allo'antibodies to a deficient coagulation factor is arguably
now the most severe and important complication of clotting factor concentrate exposure in …

At first sight the bleeding disorder hemophilia A seems to have little in common with immune
disorders, but immunology research intersects with other disciplines including hematology …

The pathogenesis of inhibitory antibodies has been the focus of major scientific interest over
the last decades, and several studies on underlying immune mechanisms and risk factors for …

Pathogenic antibodies targeting coagulation factors usually are clinically significant because
they inhibit function.'Circulating anticoagulants' were recognized as early as 1906 ([1], cited …

The pathologic role of autoantibodies in autoimmune disease is widely accepted. Recently,
we reported that anti-myelin basic protein (MBP) serum Abs from multiple sclerosis (MS) …

Immunoglobulins are known to combine various effector mechanisms of the adaptive and
the innate immune system. Classical immunoglobulin functions are associated with antigen …

Recombinant blood clotting factor VIII is one of the most complex proteins for industrial
manufacturing due to the low efficiency of its gene transcription, massive intracellular loss of …