The genetics of celiac disease: A comprehensive review of clinical implications
R Dieli-Crimi, MC Cénit, C Nunez - Journal of autoimmunity, 2015 - Elsevier
Celiac disease (CD) is a complex immune-related disease with a very strong genetic
component. Multiple genetic findings over the last decade have added to the already known …
component. Multiple genetic findings over the last decade have added to the already known …
[HTML][HTML] Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies
IM Akcay, S Katrinli, K Ozdil, GD Doganay… - World journal of …, 2018 - ncbi.nlm.nih.gov
The clinical outcome of hepatitis B virus (HBV) infection depends on the success or failure of
the immune responses to HBV, and varies widely among individuals, ranging from …
the immune responses to HBV, and varies widely among individuals, ranging from …
Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis
CJ Rhodes, K Batai, M Bleda, M Haimel… - The Lancet …, 2019 - thelancet.com
Background Rare genetic variants cause pulmonary arterial hypertension, but the
contribution of common genetic variation to disease risk and natural history is poorly …
contribution of common genetic variation to disease risk and natural history is poorly …
Accurate prediction of HLA class II antigen presentation across all loci using tailored data acquisition and refined machine learning
JB Nilsson, S Kaabinejadian, H Yari, MGD Kester… - Science …, 2023 - science.org
Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II
molecules is crucial for rational development of immunotherapies and vaccines targeting …
molecules is crucial for rational development of immunotherapies and vaccines targeting …
[PDF][PDF] Identification of functional and expression polymorphisms associated with risk for antineutrophil cytoplasmic autoantibody–associated vasculitis
Objective To identify risk alleles relevant to the causal and biologic mechanisms of
antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods A …
antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods A …
A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation
The importance of HLA-DPB1 matching for the outcome of allogeneic hematologic stem cell
(HSC) transplantation is controversial. We have previously identified HLA-DPB1* 0901 as a …
(HSC) transplantation is controversial. We have previously identified HLA-DPB1* 0901 as a …
New loci associated with chronic hepatitis B virus infection in Han Chinese
Z Hu, Y Liu, X Zhai, J Dai, G Jin, L Wang, L Zhu… - Nature …, 2013 - nature.com
Chronic hepatitis B virus (HBV) infection is a challenging global health problem. To identify
genetic loci involved in chronic HBV infection, we designed a three-phase genome-wide …
genetic loci involved in chronic HBV infection, we designed a three-phase genome-wide …
[PDF][PDF] Genetic variants in human leukocyte antigen/DP‐DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development
L Hu, X Zhai, J Liu, M Chu, S Pan, J Jiang… - …, 2012 - Wiley Online Library
Recent genome‐wide association studies showed that four single‐nucleotide
polymorphisms (SNPs) in human leukocyte antigen (HLA)‐DP (rs3077and rs9277535) and …
polymorphisms (SNPs) in human leukocyte antigen (HLA)‐DP (rs3077and rs9277535) and …
In silico identification of supertypes for class II MHCs
IA Doytchinova, DR Flower - The Journal of Immunology, 2005 - journals.aai.org
The development of epitope-based vaccines, which have wide population coverage, is
greatly complicated by MHC polymorphism. The grouping of alleles into supertypes, on the …
greatly complicated by MHC polymorphism. The grouping of alleles into supertypes, on the …
[HTML][HTML] The impact of amino acid variability on alloreactivity defines a functional distance predictive of permissive HLA-DPB1 mismatches in hematopoietic stem cell …
P Crivello, L Zito, F Sizzano, E Zino, M Maiers… - Biology of Blood and …, 2015 - Elsevier
A major challenge in unrelated hematopoietic stem cell transplantation (HSCT) is the
prediction of permissive HLA mismatches, ie, those associated with lower clinical risks …
prediction of permissive HLA mismatches, ie, those associated with lower clinical risks …