Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization

L van der Koog, TB Gandek… - Advanced healthcare …, 2022 - Wiley Online Library
Over the past decades, lipid‐based nanoparticle drug delivery systems (DDS) have caught
the attention of researchers worldwide, encouraging the field to rapidly develop improved …

[HTML][HTML] Design strategies and application progress of therapeutic exosomes

C Liu, C Su - Theranostics, 2019 - ncbi.nlm.nih.gov
Exosomes have great potential to be drug delivery vehicles due to their natural material
transportation properties, intrinsic long-term circulatory capability, and excellent …

The role of extracellular vesicles in COVID-19 virus infection

M Hassanpour, J Rezaie, M Nouri, Y Panahi - Infection, Genetics and …, 2020 - Elsevier
Extracellular vesicles releasing from various types of cells contribute to intercellular
communication via delivering bio-molecules like nucleic acids, proteins, and lipids to …

In vitro and in vivo RNA inhibition by CD9-HuR functionalized exosomes encapsulated with miRNA or CRISPR/dCas9

Z Li, X Zhou, M Wei, X Gao, L Zhao, R Shi, W Sun… - Nano …, 2018 - ACS Publications
In vitro and in vivo delivery of RNAs of interest holds promise for gene therapy. Recently,
exosomes are considered as a kind of rational vehicle for RNA delivery, especially miRNA …

Scalable production of extracellular vesicles and its therapeutic values: a review

CY Ng, LT Kee, ME Al-Masawa, QH Lee… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …

Quantification of protein cargo loading into engineered extracellular vesicles at single‐vesicle and single‐molecule resolution

AM Silva, E Lázaro‐Ibáñez… - Journal of …, 2021 - Wiley Online Library
Abstract Extracellular Vesicles (EVs) have been intensively explored for therapeutic delivery
of proteins. However, methods to quantify cargo proteins loaded into engineered EVs are …

Reprogramming the tumor microenvironment by genome editing for precision cancer therapy

K Liu, JJ Cui, Y Zhan, QY Ouyang, QS Lu, DH Yang… - Molecular Cancer, 2022 - Springer
The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

JC Polanco, GR Hand, A Briner, C Li, J Götz - Acta neuropathologica, 2021 - Springer
The microtubule-associated protein tau has a critical role in Alzheimer's disease and other
tauopathies. A proposed pathomechanism in the progression of tauopathies is the trans …

Boosting the biogenesis and secretion of mesenchymal stem cell-derived exosomes

J Wang, EE Bonacquisti, AD Brown, J Nguyen - Cells, 2020 - mdpi.com
A limitation of using exosomes to their fullest potential is their limited secretion from cells, a
major bottleneck to efficient exosome production and application. This is especially true for …

[HTML][HTML] Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

SAA Kooijmans, OG de Jong, RM Schiffelers - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are submicron cell-secreted structures containing proteins,
nucleic acids and lipids. EVs can functionally transfer these cargoes from one cell to another …