Gene therapy for human sensorineural hearing loss
Hearing loss is the most common sensory impairment in humans and currently disables 466
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …
On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament
N Peeleman, D Verdoodt, P Ponsaerts… - Frontiers in …, 2020 - frontiersin.org
The spiral ligament in the cochlea has been suggested to play a significant role in the
pathophysiology of different etiologies of strial hearing loss. Spiral ligament fibrocytes …
pathophysiology of different etiologies of strial hearing loss. Spiral ligament fibrocytes …
Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging
The human cochlea transforms sound waves into electrical signals in the acoustic nerve
fibers with high acuity. This transformation occurs via vibrating anisotropic membranes …
fibers with high acuity. This transformation occurs via vibrating anisotropic membranes …
An approach for individualized cochlear frequency mapping determined from 3D synchrotron radiation phase-contrast imaging
Objective: Cochlear implants are traditionally programmed to stimulate according to a
generalized frequency map, where individual anatomic variability is not considered when …
generalized frequency map, where individual anatomic variability is not considered when …
Synchrotron radiation-based reconstruction of the human spiral ganglion: implications for cochlear implantation
Objective: To three-dimensionally reconstruct Rosenthal's canal (RC) housing the human
spiral ganglion (SG) using synchrotron radiation phase-contrast imaging (SR-PCI). Straight …
spiral ganglion (SG) using synchrotron radiation phase-contrast imaging (SR-PCI). Straight …
Cytokine levels in inner ear fluid of young and aged mice as molecular biomarkers of noise-induced hearing loss
Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide,
frequently caused by noise trauma and aging, with inflammation being implicated in both …
frequently caused by noise trauma and aging, with inflammation being implicated in both …
The panoramic ECAP method: estimating patient-specific patterns of current spread and neural health in cochlear implant users
The knowledge of patient-specific neural excitation patterns from cochlear implants (CIs) can
provide important information for optimizing efficacy and improving speech perception …
provide important information for optimizing efficacy and improving speech perception …
Characterization of the human helicotrema: implications for cochlear duct length and frequency mapping
L Helpard, H Li, H Rask-Andersen… - … -Head & Neck …, 2020 - journals.sagepub.com
Background Despite significant anatomical variation amongst patients, cochlear implant
frequency-mapping has traditionally followed a patient-independent approach. Basilar …
frequency-mapping has traditionally followed a patient-independent approach. Basilar …
Cochlear histopathology in human genetic hearing loss: state of the science and future prospects
K Bommakanti, JS Iyer, KM Stankovic - Hearing research, 2019 - Elsevier
Sensorineural hearing loss (SNHL) is an extraordinarily common disability, affecting 466
million people across the globe. Half of these incidents are attributed to genetic mutations …
million people across the globe. Half of these incidents are attributed to genetic mutations …
Adeno-associated virus gene replacement for recessive inner ear dysfunction: Progress and challenges
Approximately 3 in 1000 children in the US under 4 years of age are affected by hearing
loss. Currently, cochlear implants represent the only line of treatment for patients with severe …
loss. Currently, cochlear implants represent the only line of treatment for patients with severe …