The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …

Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …

Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications
fail to control seizures in 20–30% of patients. However, our understanding of the …

Glial cells are now recognized as active communication partners in the central nervous
system, and this new perspective has rekindled the question of their role in pathology. In the …

Descriptions of epileptic seizures and epilepsy date back to antiquity, and research into
fundamental mechanisms of epilepsy in animal models, as well as patients, has been …

Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …

Animal seizure and epilepsy models continue to play an important role in the early discovery
of new therapies for the symptomatic treatment of epilepsy. Since 1937, with the discovery of …

Epilepsy is one of the most common serious neurological conditions, and 30 to 40% of
people with epilepsy have seizures that are not controlled by medication. Patients are …

Neurodegenerative diseases are relentlessly progressive, severely impacting affected
patients, families and society as a whole. Increased life expectancy has made these …

This article describes the recent advances in epileptogenesis and novel therapeutic
approaches for the prevention of epilepsy, with a special emphasis on the pharmacological …