In patients presenting with a clinically isolated syndrome, MRI can support and substitute
clinical information in the diagnosis of multiple sclerosis by showing disease dissemination …

Multiple sclerosis is a major cause of neurological disability, which accrues predominantly
during progressive forms of the disease. Although development of multifocal inflammatory …

Objective Gray matter (GM) damage and meningeal inflammation have been associated
with early disease onset and a more aggressive disease course in multiple sclerosis (MS) …

Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune demyelinating
diseases of the central nervous system (CNS), having distinct immunological and …

MS is heterogeneous with respect to clinical, genetic, radiographic, and pathologic features;
surrogate MRI, clinical, genetic, serologic, and/or CSF markers for each of the four …

Objective: To determine the frequency and nature of leptomeningeal contrast enhancement
in multiple sclerosis (MS) via in vivo 3-tesla postcontrast T2-weighted, fluid-attenuated …

The paired thalamic nuclei are gray matter (GM) structures on both sides of the third ventricle
that play major roles in cortical activation, relaying sensory information to the higher cortical …

Histology permits the observation of otherwise invisible structures of the internal topography
of a specimen. Although it enables the investigation of tissues at a cellular level, it is invasive …

Cortical inflammatory lesions have been correlated with disability and cortical atrophy in
multiple sclerosis. The extent to which cortical lesion load is associated with longer-term …