Abstract Phosphatidylinositol 4-phosphate (PI4P) is a membrane glycerophospholipid and a
major regulator of the characteristic appearance of the Golgi complex as well as its vesicular …

Megakaryocyte-derived platelets and endothelial cells store their hemostatic cargo in α-and
δ-granules and Weibel-Palade bodies, respectively. These storage granules belong to the …

Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store
factors regulating vascular hemostasis and local inflammation. Endothelial activation …

How can anterograde membrane trafficking be modulated by physiological cues? A screen
of Golgi-associated proteins revealed that the ARF-GEF GBF1 can selectively modulate the …

In response to tissue injury, within seconds the ultra-large glycoprotein von Willebrand factor
(VWF) is released from endothelial storage organelles (Weibel− Palade bodies) into the …

BACKGROUND: Weibel-Palade bodies (WPBs) are endothelial cell–specific cigar-shaped
secretory organelles containing various biologically active molecules. WPBs play crucial …

Melanosomes are pigment cell-specific lysosome-related organelles in which melanin
pigments are synthesized and stored. Melanosome maturation requires delivery of …

Weibel-Palade bodies (WPBs) are rod or cigar-shaped secretory organelles that are formed
by the vascular endothelium. They contain a diverse set of proteins that either function in …

The type II phosphatidylinositol 4‐kinases (PI4KIIs) produce the lipid phosphatidylinositol 4‐
phosphate (PtdIns4P) and participate in a confusing variety of membrane trafficking and …

Phosphoinositides (PIs) are small, phosphorylated lipids that serve many functions in the
cell. They regulate endo-and exocytosis, vesicular trafficking, actin reorganization, and cell …