The fission yeast Schizosaccharomyces pombe is a popular model system, and has been
particularly influential in studies of the cell cycle and chromosome dynamics. Despite its …

Large structural variations (SVs) within genomes are more challenging to identify than
smaller genetic variants but may substantially contribute to phenotypic diversity and …

Data on absolute molecule numbers will empower the modeling, understanding, and
comparison of cellular functions and biological systems. We quantified transcriptomes and …

Motivation: Spotted arrays are often printed with probes in duplicate or triplicate, but current
methods for assessing differential expression are not able to make full use of the resulting …

Recent data from several organisms indicate that the transcribed portions of genomes are
larger and more complex than expected, and that many functional properties of transcripts …

Cell-cycle control of transcription seems to be universal, but little is known about its global
conservation and biological significance. We report on the genome-wide transcriptional …

Yeast cells respond to stress by mediating condition-specific gene expression changes and
by mounting a common response to many stresses, called the environmental stress …

Plant mitochondria contain non-phosphorylating bypasses of the respiratory chain,
catalysed by the alternative oxidase (AOX) and alternative NADH dehydrogenases (NDH) …

The complexity of many cellular and organismal traits results from the integration of genetic
and environmental factors via molecular networks. Network structure and effect propagation …

Interactions between an organism and its environment can significantly influence phenotypic
evolution. A first step toward understanding this process is to characterize phenotypic …