Cryptococcal meningitis

L Tugume, K Ssebambulidde, J Kasibante… - Nature Reviews …, 2023 - nature.com
Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …

Global Molecular Epidemiology of Cryptococcus neoformans and Cryptococcus gattii: An Atlas of the Molecular Types

M Cogliati - Scientifica, 2013 - Wiley Online Library
Cryptococcosis is a fungal disease affecting more than one million people per year
worldwide. The main etiological agents of cryptococcosis are the two sibling species …

Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box

JW Kronstad, R Attarian, B Cadieux, J Choi… - Nature reviews …, 2011 - nature.com
Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …

Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff …

A Espinel-Ingroff, AI Aller, E Canton… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Epidemiological cutoff values (ECVs) for the Cryptococcus neoformans-Cryptococcus gattii
species complex versus fluconazole, itraconazole, posaconazole, and voriconazole are not …

Polyploid titan cells produce haploid and aneuploid progeny to promote stress adaptation

AC Gerstein, MS Fu, L Mukaremera, Z Li, KL Ormerod… - MBio, 2015 - Am Soc Microbiol
Cryptococcus neoformans is a major life-threatening fungal pathogen. In response to the
stress of the host environment, C. neoformans produces large polyploid titan cells. Titan cell …

Breakage-fusion-bridge cycles and large insertions contribute to the rapid evolution of accessory chromosomes in a fungal pathogen

D Croll, M Zala, BA McDonald - PLoS Genetics, 2013 - journals.plos.org
Chromosomal rearrangements are a major driver of eukaryotic genome evolution, affecting
speciation, pathogenicity and cancer progression. Changes in chromosome structure are …

Genotypic diversity is associated with clinical outcome and phenotype in cryptococcal meningitis across Southern Africa

MA Beale, W Sabiiti, EJ Robertson… - PLoS neglected …, 2015 - journals.plos.org
Cryptococcal meningitis is a major cause of mortality throughout the developing world, yet
little is known about the genetic markers underlying Cryptococcal virulence and patient …

Cryptococcus neoformans host adaptation: toward biological evidence of dormancy

A Alanio, F Vernel-Pauillac, A Sturny-Leclère, F Dromer - MBio, 2015 - Am Soc Microbiol
Cryptococcosis is an opportunistic infection due to the ubiquitous yeast Cryptococcus
neoformans. This yeast interacts closely with innate immune cells, leading to various fates …

A population genomics approach to assessing the genetic basis of within-host microevolution underlying recurrent cryptococcal meningitis infection

J Rhodes, MA Beale, M Vanhove… - G3: Genes …, 2017 - academic.oup.com
Recurrence of meningitis due to Cryptococcus neoformans after treatment causes
substantial mortality in HIV/AIDS patients across sub-Saharan Africa. In order to determine …

Animal Models of Cryptococcus neoformans in Identifying Immune Parameters Associated With Primary Infection and Reactivation of Latent Infection

TG Normile, AM Bryan, M Del Poeta - Frontiers in Immunology, 2020 - frontiersin.org
Cryptococcus species are environmental fungal pathogens and the causative agents of
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …