FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

AMPK is an important kinase regulating energy homeostasis and also a key protein involved
in a variety of signal transduction pathways. It plays a vitally regulatory role in cellular …

Abstract N6‐methyladenosine (m6A) is an abundant nucleotide modification in mRNA,
known to regulate mRNA stability, splicing, and translation, but it is unclear whether it is also …

Background: Exercise is an effective nonpharmacological strategy to alleviate diabetic
cardiomyopathy (DCM) through poorly defined mechanisms. FGF21 (fibroblast growth factor …

Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for
fine-tuning the spatial and temporal expression of a broad range of genes both during …

FOXO transcription factors are conserved regulators of longevity downstream of insulin
signaling. These transcription factors integrate signals emanating from nutrient deprivation …

Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified
cellular housekeeping are the hallmarks of improved healthspan and extended lifespan …

The Sir2 deacetylase modulates organismal life-span in various species. However, the
molecular mechanisms by which Sir2 increases longevity are largely unknown. We show …

Cellular stress response is a universal mechanism that ensures the survival or negative
selection of cells in challenging conditions. The transcription factor Forkhead box protein O3 …