The production of recombinant proteins is one of the major successes of biotechnology.
Animal cells are required to synthesize proteins with the appropriate post-translational …

Different systems are being studied and used to prepare recombinant proteins for
pharmaceutical use. The blood, and still more the milk, from transgenic animals appear a …

The extracellular matrix (ECM) is an important regulator of the differentiated phenotype of
mammary epithelial cells in culture. Despite the fact that ECM-degrading enzymes have …

Matrix-attachment regions (MARs) may function as domain boundaries and partition
chromosomes into independently regulated units. We have tested whether MAR sequences …

Pit-1 is a tissue-specific POU domain factor obligatory for the appearance of three cell
phenotypes in the anterior pituitary gland. Expression of the pit-1 gene requires the actions …

Interspecies comparisons of cDNA and mosaic milk protein genes have confirmed their high
rate of evolution, but the overall gene organization has been conserved. The three Ca …

Much of our understanding of GH's action stems from animal models and the generation and
characterization of genetically altered or modified mice. Manipulation of genes in the …

Abstract Her-2 transgenic (Tg) mice were generated with wild-type human c-ErbB-2 (Her-2)
under the whey acidic protein promoter. They are tolerant to Her-2 and appropriate for …

Deficiency or abnormality of coagulation factor VIII (FVIII) causes a bleeding disorder called
hemophilia A. Treatment involves FVIII concentrates prepared from pooled human plasma or …

Using the phage P1-derived Cre/loxP recombination system, we have developed a strategy
for efficient mammary tissue specific inactivation of floxed genes. Transgenic mice were …