Controlled pulmonary drug and gene delivery using polymeric nano-carriers

M Beck-Broichsitter, OM Merkel, T Kissel - Journal of controlled release, 2012 - Elsevier
Pulmonary drug and gene delivery to the lung represents a non-invasive avenue for local
and systemic therapies. However, the respiratory tract provides substantial barriers that …

siRNA therapeutics against respiratory viral infections—What have we learned for potential COVID‐19 therapies?

A Mehta, T Michler, OM Merkel - Advanced healthcare materials, 2021 - Wiley Online Library
Acute viral respiratory tract infections (AVRIs) are a major burden on human health and
global economy and amongst the top five causes of death worldwide resulting in an …

Comparison of intrapulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and colistin after aerosol delivery and intravenous administration of …

M Boisson, M Jacobs, N Grégoire, P Gobin… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Colistin is an old antibiotic that has recently gained a considerable renewal of interest for the
treatment of pulmonary infections due to multidrug-resistant Gram-negative bacteria …

Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells

CA Fromen, TB Rahhal, GR Robbins, MP Kai… - … , Biology and Medicine, 2016 - Elsevier
Engineered nanoparticles have the potential to expand the breadth of pulmonary
therapeutics, especially as respiratory vaccines. Notably, cationic nanoparticles have been …

Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide

SK Debnath, S Saisivam, M Debanth, A Omri - PloS one, 2018 - journals.plos.org
Prothionamide (PTH), a second line antitubercular drug is used to administer in
conventional oral route. However, its unpredictable absorption and frequent administration …

Building three-dimensional lung models for studying pharmacokinetics of inhaled drugs

AS Barros, A Costa, B Sarmento - Advanced drug delivery reviews, 2021 - Elsevier
Drug development is a critical step in the development pipeline of pharmaceutical industry,
commonly performed in traditional cell culture and animal models. Though, those models …

Carrier interactions with the biological barriers of the lung: advanced in vitro models and challenges for pulmonary drug delivery

C de Souza Carvalho, N Daum, CM Lehr - Advanced Drug Delivery …, 2014 - Elsevier
In recent years significant progress has been made to improve particle deposition in the
lung. However, the development of strategies to overcome the air–blood lung barrier is still …

[HTML][HTML] Nebulised delivery of RNA formulations to the lungs: From aerosol to cytosol

MT Neary, LM Mulder, PS Kowalski… - Journal of Controlled …, 2024 - Elsevier
In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …

Nanocarriers for anticancer drugs-new trends in nanomedicine

J Drbohlavova, J Chomoucka, V Adam… - Current drug …, 2013 - ingentaconnect.com
This review provides a brief overview of the variety of carriers employed for targeted drug
delivery used in cancer therapy and summarizes advantages and disadvantages of each …

Ultrasonic nebulization platforms for pulmonary drug delivery

LY Yeo, JR Friend, MP McIntosh… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: Since the 1950s, ultrasonic nebulizers have played an important role
in pulmonary drug delivery. As the process in which aerosol droplets are generated is …